Omega-6 Levels in Brain Linked to Depression
A new study found that depressed rats had higher levels of Omega-6 fatty acids in their brains. The researchers were surprised:
“The finding that in the depressive rats the omega-3 fatty acid levels were not decreased, but arachidonic acid was substantially increased as compared to controls is somewhat unexpected.”
Arachidonic acid is a metabolite (or product) of omega-6 fatty acids, which are found in heavy abundance in most vegetable oils. So how does supplementation with omega-3 fatty acids relieve depression? The answer lies in the relationship between omega-3 and omega-6 fatty acids. Put on your thinking caps, folks, it’s time for a science lesson! Don’t worry, it’s easy to understand.
Omega-6s are metabolized in the body to become Arachidonic Acid. Arachidonic Acid is a precursor to pro-inflammatory eicosanoids, or hormone-like substances that increase inflammation in the body. While redness, heat, swelling and pain are the more commonly-known products of inflammation, a lesser known product is the dysfunction of the organ involved. Elevated levels of arachidonic acid in the brain actually cause dysfunction of the brain, thus causing depression! Or ADHD. Perhaps even Alzheimers. The list goes on and on. So how do the omega-3s fit in?
To put things simply, the omega-3 fatty acids compete with the omega-6 fatty acids for the chemicals required to convert the omega-6s into arachidonic acid, effectively neutralizing them. We need inflammation for when an infection or injury occurs, but we also need the omega-3s to allow the inflammation to subside. When you have a balance of the two, you remain well. When you have too many omega-6s and too few omega-3s, inflammation proliferates and so does dysfunction of the inflamed organs. What then happens from the system-wide inflammation is system-wide dysfunction, resulting in not just depression, but eventually also heart disease, Type II (Adult-Onset) Diabetes, ADHD and a host of other health issues.
Would the researchers agree? Let’s see what they had to say:
“But the finding lends itself nicely to the theory that increased omega-3 fatty acid intake may shift the balance between the two fatty acid families in the brain, since it has been demonstrated in animal studies that increased omega-3 fatty acid intake may result in decreased brain arachidonic acid.”
Tags: arachadonic acid, depression, inflammation, omega-3s, omega-6s
I’ve suffered serious depression and ADHD since I was a teenager. Of course, all my life, my diet was junk food, fast food, comfort food… I’ve tried Ritalin, Paxil, Prozac and none have helped. I decided, since reading some research on Omega-3’s to go ahead and try changing my diet to add more tuna, salmon, and once in a while a can of sardines. I noticed an immediate difference within days.. You know, over the years, I believe I’ve really deprived my body of what it needs, but everyone’s body has different needs. I am just happy to have found them out. Fish Oil is a miracle from God.
just strted takinf fish oil for depression, anxiety, ocd….does it really work…antideptessants never worked and made me feel razy….
I take about 5 capsules a day, in the morning. of a 600-400 ratio of Epa to dha fish oil supplement, for depression. I have seen recommendations of 4 grams daily. I absolutely think it is effective.
Can this amount cause insomnia?
Is there a specified time which is recommended for taking fish oil? Is is better to space it out through out the day?
Can diarreah result from so high a dosage?
I started taking fish oil and I am also undergoing eft training I hope the combination of this two will really help me overcome my depression mode.
Thanks for the interesting post on depression. I look forward to reading more posts from you in the future.